Deng Adel led the way for the Cardinals with 21 points on 7-of-14 from the floor, but Louisville was ice cold from three-point range and that ultimately was their undoing.
Ranked 10th in the nation in the latest Associated Press Top 25 Poll, the Cardinals still seem on track for a second seed, or at worst a third, in the NCAA Tournament when the brackets are announced on Selection Sunday.
While Louisville sits and wait, the Blue Devils move on to play North Carolina in a potentially riveting ACC Tournament semi-final.
For a team that won the ACC regular season crown, and by two full games over Florida State, Louisville and Notre Dame, the Tar Heels are peculiarly under the radar as we head towards the NCAA Tournament.
North Carolina, ranked sixth in the nation behind Kansas, Villanova, UCLA, Gonzaga and Oregon, has lost just six times with defeats to Indiana, Kentucky, Georgia Tech, Miami, Duke and Virginia.
The Tar Heels shot a miserable 35.4 per cent from the floor in their loss to the Cavaliers in Charlottesville, but in general have quietly gone about their business.
Meanwhile, the other semi-final will feature the Seminoles of Florida State against the Fighting Irish of Notre Dame. Both could use a win, particularly the latter, to increase their overall profile with the seeding committee.